INDICATIONS

• Ultrashort-acting non-analgesic hypnotic/sedative drug that is non-benzodiazepine or barbiturate
• Provides sedation with little cardiovascular or respiratory depression
• Safer choice for hypotensive patients
• Decreases cerebral blood flow, cerebral metabolic rate, and ICP (intracranial pressure)

PRECAUTIONS

• May suppress cortisol production (consider hydrocortisone stress dose – 2 mg/kg, max dose = 100 mg)
• Use cautiously in septic shock
• Can cause myoclonic activity and worsen focal seizures
• Best to avoid in patients with adrenal insufficiency or focal seizures

DOSAGE & ADMINISTRATION

For rapid sedation:

• IV/IO: 0.2–0.4 mg/kg infused over 30–60 seconds, providing sedative effects for 10–15 minutes
• Maximum dose is 20 mg