Antiarrhythmic agent
- Uses: a variety of supraventricular and ventricular arrhythmias in children
- 2025 Guidelines mention ectopic atrial tachycardia and junctional ectopic tachycardia
- Ventricular tachycardia and fibrillation
CAUTIONS
- May induce hypotension
- QT prolongation (polymorphic ventricular arrhythmias)
- If considering use in combination with procainamide, acquire expert consultation
- Use with caution if hepatic failure is present
- Extremely long elimination; loading may take up to 40 days
DOSAGE & ADMINISTRATION
Refractory ventricular fibrillation or pulseless VT:
- 5 mg/kg IV/IO bolus (maximum 300 mg)
- DO NOT DELAY CARDIOVERSION in the presence of poor perfusion related arrhythmias